Brazilian researchers recently published results of a study involving 196 men and women between the ages of 18 and 65, to find out whether melatonin could an effective migraine treatment.  To be eligible to participate in the study patients needed to have experienced a baseline 2 – 8 migraine attacks every month.  Patients were then introduced to melatonin 3mg, amitriptyline 25mg or a simple placebo for the control group.

Researchers found was that migraine attacks for those taking melatonin 3mg were reduced by 2.7 migraine headache days each month, compared to a reduction of 2.2 days for those taking amitriptyline.  Placebo group reported reduced migraine headache days of 1.1 days per month.

Research paper is accessible at The Journal of Neurology, Neurosurgery & Psychiatry.